The causative agent of tuberculosis (TB), Mycobacterium tuberculosis, infects roughly a third of the world's population. Much of this is sub-clinical and latent.

TB pathogenesis research currently focuses on delineating the mechanism of latency and reactivation from latency. 

  • The laboratory has been studying a family of operons called mce (mce1-4) that resemble ABC transporters, possibly involved in lipid transport across the cell wall of M. tuberculosis. The phenotype of mutants disrupted in the operon are studied in mouse models.

  • The basic pathogenesis research has led to several translational research activities

    • The development of a new therapeutic/adjunct TB vaccine

    • New biomarker-based diagnostic and prognostic tests for TB.

KEY Publications

Patents 

Serological lipid-antibody assay for monitoring tuberculosis treatment response in children and HIV co-infected patients. WO 2012/151039. 11/8/2012

MEMBERS CURRENTLY ACTIVE IN TB RESEARCH

 

 Photos: Mycobacterial infections of macrophages with immune effector proteins labeled; (1) blue is a nuclear counterstain, p62 (green), and mycobacteria (red). (2) p62 (red), mycobacteria (green), hoechst DNA (blue) (3) mycobacteria(red), confocal-LC3(green), colocalization. Credit- Michael Schump